Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells


  • The authors thank the Hybridoma Facility and the Laboratory Animal Resources Office of Iowa State University for providing the blood samples. This work was supported by the U.S. National Science Foundation (CHE-0809521) and by the U.S. Department of Energy, Office of Basic Energy Sciences under Contract No. DE-AC02-07CH11358.


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The hemolytic properties of amorphous silica and MCM-41-type mesoporous silica nanoparticles (MSNs) with rabbit red blood cells (RBCs) are compared. The amorphous silica exhibits a high hemolytic activity toward the RBCs. In contrast, a high biocompatibility between the MSNs and the RBCs is observed. The low hemolytic activity of the MSNs offers promising potential for various in vivo biotechnological applications.