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Destruction and Control of Toxoplasmagondii Tachyzoites Using Gold Nanosphere/Antibody Conjugates

Authors

  • Dakrong Pissuwan,

    1. Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
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  • Stella M. Valenzuela,

    1. Department of Molecular and Bioscience University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
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  • Catherine M. Miller,

    1. Institute for the Biotechnology of Infectious Disease University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007, (Australia)
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  • Murray C. Killingsworth,

    1. Sydney South West Pathology Service Locked Bag 7090 Liverpool BC, NSW, 1871 (Australia)
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  • Michael B. Cortie

    Corresponding author
    1. Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia)
    • Institute for Nanoscale Technology University of Technology Sydney P.O. Box 123, Broadway, Sydney, NSW 2007 (Australia).
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  • This work was supported by the University of Technology Sydney. We thank Dr. Brian Reedy and Mr. Michael Lees for technical support.

Abstract

original image

The protozoan parasiteToxoplasma gondii can be selectively targeted and photothermally destroyed by gold nanosphere/antibody conjugates (see image). The optical response of the nanospheres within the “tissue window” is shifted and enhanced by aggregation. Attachment of the conjugates alone, even without plasmonic heating, lowers the infectivity of the organism.

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