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Virus-Templated Silica Nanoparticles

Authors

  • Nicole F. Steinmetz,

    Corresponding author
    1. Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK)
    2. Present Address: Department of Cell Biology Center of Integrative Molecular Biosciences The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    • Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK).
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  • Sachin N. Shah,

    1. Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK)
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  • J. Elaine Barclay,

    1. Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK)
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  • Ghanasyam Rallapalli,

    1. Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK)
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  • George P. Lomonossoff,

    1. Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK)
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  • David. J. Evans

    Corresponding author
    1. Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK)
    • Department of Biological Chemistry, John Innes Centre Norwich Research Park, Colney, Norwich, NR4 7UH (UK).
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  • Dr. N. F. Steinmetz and Dr. S. Shah contributed equally to this research. The Biotechnology and Biological Sciences Research Council, UK (Core Strategic Grant to the John Innes Centre and Grant BB/E024939/1 {S.S}) and the EU Marie Curie Early Stage Training Scheme (MEST-CT-2004-504273 {N.F.S}) are thanked for funding. K. Findlay and S. Bunnewell, JIC, are thanked for assistance with TEM and R. Evans-Gowing, University of East Anglia, for EDX measurements, and A. Kirby, IFR, for NTA measurements.

Abstract

original image

An engineered variant of the plant virus, Cowpea mosaic virus, can template the controlled fabrication of silica nanoparticles of ≈30-nm diameter under environmentally benign conditions at ambient temperature and in aqueous solvent. This is the first reported mineralization of the external surface of a cage-like viral bionanoparticle (see image).

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