Large-Area, Nanoimprint-Assisted Microcontact Stripping for the Fabrication of Microarrays of Fouling/Nonfouling Nanostructures

Authors

  • Ana Ruiz,

    1. European Commission, DG-JRC Institute for Health and Consumer Protection TP 203, Via Enrico Fermi 2749, 21027-Ispra (Italy)
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  • Christopher A Mills,

    1. Nanobioengineering group Institute for Bioengineering of Catalonia (IBEC) Barcelona Science Park C/ Josep Samitier 1-5, 08028 Barcelona (Spain)
    2. Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Barcelona (Spain)
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  • Andrea Valsesia,

    1. European Commission, DG-JRC Institute for Health and Consumer Protection TP 203, Via Enrico Fermi 2749, 21027-Ispra (Italy)
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  • Elena Martinez,

    1. Nanobioengineering group Institute for Bioengineering of Catalonia (IBEC) Barcelona Science Park C/ Josep Samitier 1-5, 08028 Barcelona (Spain)
    2. Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Barcelona (Spain)
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  • Giacomo Ceccone,

    1. European Commission, DG-JRC Institute for Health and Consumer Protection TP 203, Via Enrico Fermi 2749, 21027-Ispra (Italy)
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  • Josep Samitier,

    1. Nanobioengineering group Institute for Bioengineering of Catalonia (IBEC) Barcelona Science Park C/ Josep Samitier 1-5, 08028 Barcelona (Spain)
    2. Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Barcelona (Spain)
    3. Electronics Department, University of Barcelona C/ Marti i Franques 1, 08028 Barcelona (Spain)
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  • Pascal Colpo,

    1. European Commission, DG-JRC Institute for Health and Consumer Protection TP 203, Via Enrico Fermi 2749, 21027-Ispra (Italy)
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  • François Rossi

    Corresponding author
    1. European Commission, DG-JRC Institute for Health and Consumer Protection TP 203, Via Enrico Fermi 2749, 21027-Ispra (Italy)
    • European Commission, DG-JRC Institute for Health and Consumer Protection TP 203, Via Enrico Fermi 2749, 21027-Ispra (Italy).
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  • The authors would like to thank M. J. Lopez-Bosque of the Nanotechnology Platform, Barcelona Science Park, for recording the SEM images. The work was supported by the European Commission Joint Research Centre Action “NanoBiotechnology for Health” and the Nano2Life Network of Excellence. CAM acknowledges support from the Spanish Ministry of Science and Technology via the Ramon y Cajal program.

Abstract

original image

Large-area micropatterns of poly(acrylic acid) (PAA) nanodomains favorable for biological cell attachment are produced in a nonfouling poly(ethylene oxide) (PEO) matrix (see image). Nanoimprint-assisted microcontact stripping techniques are used to micropattern polystyrene nanobeads deposited on PAA. Subsequent etching of the nanobeads, followed by deposition of PEO by plasma-enhanced chemical vapor deposition, produces the fouling/non-fouling surface.

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