The work was supported by a grant (R01CA119408) from the National Cancer Institute, the National Institute of Health.
Functionalized Nanoparticles with Long-Term Stability in Biological Media†
Article first published online: 30 MAR 2009
Copyright © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 5, Issue 14, pages 1637–1641, July 17, 2009
How to Cite
Fang, C., Bhattarai, N., Sun, C. and Zhang, M. (2009), Functionalized Nanoparticles with Long-Term Stability in Biological Media. Small, 5: 1637–1641. doi: 10.1002/smll.200801647
- Issue published online: 30 JUL 2009
- Article first published online: 30 MAR 2009
- Manuscript Revised: 26 JAN 2009
- Manuscript Received: 6 NOV 2008
- National Cancer Institute, the National Institute of Health. Grant Number: R01CA119408
- surface modification
A surface-engineering approach to produce monodisperse nanoparticles functionalized for conjugations of various biomolecules is described. The oleic acid-capped nanoparticles are modified with triethoxysilylpropylsuccinic anhydride followed by reaction with aminated poly(ethylene glycol) (PEG) to render the nanoparticles hydrophilic and display amine groups at the free termini of PEG chains (see image).