Functionalized Nanoparticles with Long-Term Stability in Biological Media


  • The work was supported by a grant (R01CA119408) from the National Cancer Institute, the National Institute of Health.


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A surface-engineering approach to produce monodisperse nanoparticles functionalized for conjugations of various biomolecules is described. The oleic acid-capped nanoparticles are modified with triethoxysilylpropylsuccinic anhydride followed by reaction with aminated poly(ethylene glycol) (PEG) to render the nanoparticles hydrophilic and display amine groups at the free termini of PEG chains (see image).