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Keywords:

  • cancer;
  • DNA;
  • nanoparticles;
  • template synthesis
Thumbnail image of graphical abstract

A class of DNA aptamers, recognizing and therapeutically targeting cancer cells, remains functional while forming stable colloidal PbS and Fe3O4 nanocrystals. The aptamer-passivated nanocrystals (see image) are non-cytotoxic to normal cells, whereas MCF-7 human breast cancer cells incorporated with these particles have significantly reduced proliferation. The nanoparticle-aptamer systems provide a platform for novel nanoparticle therapeutics.