We gratefully acknowledge financial support through NSF Career and Beckman Young Investigator Awards (to M.S.S.). K.H.C. acknowledges the National Science Scholarship from the Agency for Science, Technology and Research of Singapore. J.-H.H. acknowledges support from the Korea Research Foundation (MOEHRD, KRF-2006-214-D00117).
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Communication
DNA Aptamer-Passivated Nanocrystal Synthesis: A Facile Approach for Nanoparticle-Based Cancer Cell Growth Inhibition†
Article first published online: 23 FEB 2009
DOI: 10.1002/smll.200801821
Copyright © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Choi, J. H., Chen, K. H., Han, J.-H., Chaffee, A. M. and Strano, M. S. (2009), DNA Aptamer-Passivated Nanocrystal Synthesis: A Facile Approach for Nanoparticle-Based Cancer Cell Growth Inhibition. Small, 5: 672–675. doi: 10.1002/smll.200801821
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Publication History
- Issue published online: 22 MAR 2009
- Article first published online: 23 FEB 2009
- Manuscript Received: 5 DEC 2008
Keywords:
- cancer;
- DNA;
- nanoparticles;
- template synthesis
A class of DNA aptamers, recognizing and therapeutically targeting cancer cells, remains functional while forming stable colloidal PbS and Fe3O4 nanocrystals. The aptamer-passivated nanocrystals (see image) are non-cytotoxic to normal cells, whereas MCF-7 human breast cancer cells incorporated with these particles have significantly reduced proliferation. The nanoparticle-aptamer systems provide a platform for novel nanoparticle therapeutics.