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Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles


  • This research was supported by a grant from the National Research Council, Taiwan (NSC-95-2752-M-002-004-PAE).


original image

The size of it: Mesoporous silica nanoparticles (MSNs) of controlled size in the range 30 to 280 nm are obtained by adjusting the pH of the reaction solution. The uptake of fluorescein-labeled MSNs (green, see image) by HeLa cells is size-dependent, with maximum uptake at a nanoparticle size of 50 nm.