The Biocompatibility of Apoferritin-Encapsulated PbS Quantum Dots


  • This work was supported by the Medical Research Council, The Leverhulme Trust, the Engineering and Physical Sciences Research Council and The University of Nottingham. We acknowledge useful discussions with B. Hennequin.


original image

A PbS quantum dot encapsulated into the hollow core of an apoferritin protein (see image) offers several advantages over existing composites based on quantum dots including a lower level of cytotoxicity, differential toxicity between healthy and cancerous cells, emission tunable in the near-infrared wavelength range of interest for bioimaging, water solubility and stability, and the same mobility as that of apoferritin.