These authors equally contributed to this work.
Magnetic Nanoclusters for Ultrasensitive Magnetophoretic Assays†
Article first published online: 26 MAY 2009
Copyright © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 5, Issue 20, pages 2243–2246, October 16, 2009
How to Cite
Jin, Z., Hahn, Y. K., Oh, E., Kim, Y.-P., Park, J.-K., Moon, S. H., Jang, J.-T., Cheon, J. and Kim, H.-S. (2009), Magnetic Nanoclusters for Ultrasensitive Magnetophoretic Assays. Small, 5: 2243–2246. doi: 10.1002/smll.200900311
This research was supported by the Nano/Bio Science and Technology Program (2005-01291), Nano-Science & Technology Program (M10503000868-08M0300-86810), Pioneer Research Program for Converging Technology (M10711300001-08M1130-00110), WCU program (R31-2008-000-10071-0), Brain Korea 21 of MEST, and the Korea Health 21C R&D Project (A04-0041-B21004-08A5-00030B) of MIHWAF.
- Issue published online: 12 OCT 2009
- Article first published online: 26 MAY 2009
- Manuscript Received: 19 FEB 2009
- magnetic nanoclusters;
- magnetophoretic assays;
- magnetic nanoparticles;
Magnetic nanoclusters (MNCs) are developed and used for an ultrasensitive magnetophoretic assay system. Prostate-specific antigen (PSA) is used as a target analyte (see image). The deflection velocity of a microbead is well correlated with the PSA concentration, with a detection limit of 45 fg mL−1, and this value is three orders of magnitude higher than conventional ELISA. The developed assay format is expected to be effectively applied to the detection of a target analyte with low abundance.