Communication

Magnetic Nanoclusters for Ultrasensitive Magnetophoretic Assays†

  1. Zongwen Jin2,‡,
  2. Young Ki Hahn3,‡,
  3. Eunkeu Oh2,
  4. Young-Pil Kim2,
  5. Je-Kyun Park3,*,
  6. Seung Ho Moon4,
  7. Jung-Tak Jang4,
  8. Jinwoo Cheon4,
  9. Hak-Sung Kim1,*

Article first published online: 26 MAY 2009

DOI: 10.1002/smll.200900311

Issue

Small

Small

Volume 5, Issue 20, pages 2243–2246, October 16, 2009

Additional Information

How to Cite

Jin, Z., Hahn, Y. K., Oh, E., Kim, Y.-P., Park, J.-K., Moon, S. H., Jang, J.-T., Cheon, J. and Kim, H.-S. (2009), Magnetic Nanoclusters for Ultrasensitive Magnetophoretic Assays. Small, 5: 2243–2246. doi: 10.1002/smll.200900311

Author Information

  1. 1

    Department of Biological Sciences and Graduate school of Nanoscience & Technology KAIST Daejeon 305–701 (Korea)

  2. 2

    Department of Biological Sciences KAIST Daejeon 305–701 (Korea)

  3. 3

    Department of Bio and Brain Engineering KAIST Daejeon 305–701 (Korea)

  4. 4

    Department of Chemistry Yonsei University Seoul, 120–749 (Korea)

  1. ‡

    These authors equally contributed to this work.

*Department of Bio and Brain Engineering KAIST Daejeon 305–701 (Korea).

  1. †

    This research was supported by the Nano/Bio Science and Technology Program (2005-01291), Nano-Science & Technology Program (M10503000868-08M0300-86810), Pioneer Research Program for Converging Technology (M10711300001-08M1130-00110), WCU program (R31-2008-000-10071-0), Brain Korea 21 of MEST, and the Korea Health 21C R&D Project (A04-0041-B21004-08A5-00030B) of MIHWAF.

  2. ‡

    These authors equally contributed to this work.

Publication History

  1. Issue published online: 12 OCT 2009
  2. Article first published online: 26 MAY 2009
  3. Manuscript Received: 19 FEB 2009

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Keywords:

  • magnetic nanoclusters;
  • magnetophoretic assays;
  • magnetic nanoparticles;
  • microfluidics
Thumbnail image of graphical abstract

Magnetic nanoclusters (MNCs) are developed and used for an ultrasensitive magnetophoretic assay system. Prostate-specific antigen (PSA) is used as a target analyte (see image). The deflection velocity of a microbead is well correlated with the PSA concentration, with a detection limit of 45 fg mL−1, and this value is three orders of magnitude higher than conventional ELISA. The developed assay format is expected to be effectively applied to the detection of a target analyte with low abundance.

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