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Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

  1. Santimukul Santra1,
  2. Charalambos Kaittanis1,
  3. Jan Grimm2,
  4. J. Manuel Perez1,*

Article first published online: 20 APR 2009

DOI: 10.1002/smll.200900389

Issue

Small

Small

Volume 5, Issue 16, pages 1862–1868, August 17, 2009

Additional Information

How to Cite

Santra, S., Kaittanis, C., Grimm, J. and Perez, J. M. (2009), Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging. Small, 5: 1862–1868. doi: 10.1002/smll.200900389

Author Information

  1. 1

    Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA)

  2. 2

    Department of Radiology, Memorial Sloan Kettering Cancer Center 1275 York Avenue New York, NY 10065 (USA)

*Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA).

Publication History

  1. Issue published online: 5 AUG 2009
  2. Article first published online: 20 APR 2009
  3. Manuscript Received: 4 MAR 2009

Funded by

  • NIH. Grant Numbers: CA101781, GM084331

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Keywords:

  • click chemistry;
  • drug delivery;
  • magnetic materials;
  • magnetic resonance imaging

Abstract

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.

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