Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

Authors

  • Santimukul Santra,

    1. Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA)
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  • Charalambos Kaittanis,

    1. Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA)
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  • Jan Grimm,

    1. Department of Radiology, Memorial Sloan Kettering Cancer Center 1275 York Avenue New York, NY 10065 (USA)
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  • J. Manuel Perez

    Corresponding author
    1. Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA)
    • Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA).
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Abstract

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.

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