Control of the in vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings

Authors

  • Anne-Charlotte Faure,

    1. Laboratoire de Physico-Chimie des Matériaux Luminescents CNRS UMR 5620, Université Claude Bernard Lyon 1 69622 Villeurbanne Cedex (France)
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    • These authors contributed equally to the work.

  • Sandrine Dufort,

    1. CRI–INSERM U823, Institut Albert Bonniot, BP 170 38042 Grenoble Cedex 9 (France)
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    • These authors contributed equally to the work.

  • Véronique Josserand,

    1. CRI–INSERM U823, Institut Albert Bonniot, BP 170 38042 Grenoble Cedex 9 (France)
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  • Pascal Perriat,

    1. Matériaux, Ingénierie et Sciences CNRS UMR 5510, INSA de Lyon 69621 Villeurbanne Cedex (France)
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  • Jean-Luc Coll,

    Corresponding author
    1. CRI–INSERM U823, Institut Albert Bonniot, BP 170 38042 Grenoble Cedex 9 (France)
    • CRI–INSERM U823, Institut Albert Bonniot, BP 170 38042 Grenoble Cedex 9 (France).
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  • Stéphane Roux,

    Corresponding author
    1. Laboratoire de Physico-Chimie des Matériaux Luminescents CNRS UMR 5620, Université Claude Bernard Lyon 1 69622 Villeurbanne Cedex (France)
    • Laboratoire de Physico-Chimie des Matériaux Luminescents CNRS UMR 5620, Université Claude Bernard Lyon 1 69622 Villeurbanne Cedex (France).
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  • Olivier Tillement

    1. Laboratoire de Physico-Chimie des Matériaux Luminescents CNRS UMR 5620, Université Claude Bernard Lyon 1 69622 Villeurbanne Cedex (France)
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Abstract

Fluorescent nanoparticles containing a gadolinium oxide core are very attractive because they are able to combine both imaging (fluorescence imaging, magnetic resonance imaging) and therapy (X-ray therapy and neutron-capture therapy) techniques. The exploitation of these multifunctional particles for in vivo applications requires accurate control of their biodistribution. The postfunctionalization of these particles by four different poly(ethylene glycol) derivatives, which differ by chain length and end group, exerts a great influence on the ζ potential of the nanoparticles and on their biodistribution after intravenous injection to HEK-β3-tumor-bearing mice. This study reveals that the behavior of PEGylated nanoparticles, which was monitored by in vivo fluorescence imaging, depends on both the chain length and the end group of the PEG chain.

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