This work was supported by the National R&D Program for Cancer Control of the Ministry of Health & Welfare (0820320) and Nuclear R&D Programs funded by the Ministry of Science & Technology (MOST; No. 2008-03767). The authors are grateful to Dong-Su Jang for the illustration.
Multiplex Imaging of Single Tumor Cells Using Quantum-Dot-Conjugated Aptamers†
Article first published online: 27 AUG 2009
Copyright © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 5, Issue 22, pages 2519–2522, November 16, 2009
How to Cite
Kang, W. J., Chae, J. R., Cho, Y. L., Lee, J. D. and Kim, S. (2009), Multiplex Imaging of Single Tumor Cells Using Quantum-Dot-Conjugated Aptamers. Small, 5: 2519–2522. doi: 10.1002/smll.200900848
- Issue published online: 11 NOV 2009
- Article first published online: 27 AUG 2009
- Manuscript Received: 20 MAY 2009
- National R&D Program for Cancer Control of the Ministry of Health & Welfare. Grant Number: 0820320
- Ministry of Science & Technology (MOST). Grant Number: 2008-03767
- cancer detection;
- quantum dots
Aptamers conjugated with quantum dots (QDs) bind to target molecules on the cellular membrane of cancer cells. QDs with a carboxyl terminal are conjugated with three types of tumor-targeting aptamer (see picture). Various types of cancer cell are simultaneously targeted with QD-TTA1 (605nm, light green), QD-AS1411 (655nm, red), and QD-MUC-1 (705nm, violet).