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Multiplex Imaging of Single Tumor Cells Using Quantum-Dot-Conjugated Aptamers

Authors

  • Won Jun Kang,

    1. Division of Nuclear Medicine, Department of Radiology Yonsei University College of Medicine Research Institute of Radiological Science 134 Shinchon-dong, Seodaemun-gu Seoul 120-752 (Republic of Korea)
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  • Ju Ri Chae,

    1. Division of Nuclear Medicine, Department of Radiology Yonsei University College of Medicine Research Institute of Radiological Science 134 Shinchon-dong, Seodaemun-gu Seoul 120-752 (Republic of Korea)
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  • Ye Lim Cho,

    1. Division of Nuclear Medicine, Department of Radiology Yonsei University College of Medicine Research Institute of Radiological Science 134 Shinchon-dong, Seodaemun-gu Seoul 120-752 (Republic of Korea)
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  • Jong Doo Lee,

    1. Division of Nuclear Medicine, Department of Radiology Yonsei University College of Medicine Research Institute of Radiological Science 134 Shinchon-dong, Seodaemun-gu Seoul 120-752 (Republic of Korea)
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  • Soonhag Kim

    Corresponding author
    1. Laboratory of Molecular Imaging, CHA Stem Cell Institute CHA University 605-21 Yoeksam 1-dong, Gangnam-gu Seoul 135-081 (Republic of Korea)
    • Laboratory of Molecular Imaging, CHA Stem Cell Institute CHA University 605-21 Yoeksam 1-dong, Gangnam-gu Seoul 135-081 (Republic of Korea).
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  • This work was supported by the National R&D Program for Cancer Control of the Ministry of Health & Welfare (0820320) and Nuclear R&D Programs funded by the Ministry of Science & Technology (MOST; No. 2008-03767). The authors are grateful to Dong-Su Jang for the illustration.

Abstract

original image

Aptamers conjugated with quantum dots (QDs) bind to target molecules on the cellular membrane of cancer cells. QDs with a carboxyl terminal are conjugated with three types of tumor-targeting aptamer (see picture). Various types of cancer cell are simultaneously targeted with QD-TTA1 (605nm, light green), QD-AS1411 (655nm, red), and QD-MUC-1 (705nm, violet).

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