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Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles

Authors

  • Qianjun He,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-Xi Road, Shanghai 200050 (P.R. China)
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  • Zhiwen Zhang,

    1. Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchong-Zhi Road, Shanghai 201203 (P. R. China)
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  • Yu Gao,

    1. Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchong-Zhi Road, Shanghai 201203 (P. R. China)
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  • Jianlin Shi,

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-Xi Road, Shanghai 200050 (P.R. China)
    • State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-Xi Road, Shanghai 200050 (P.R. China).
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  • Yaping Li

    Corresponding author
    1. Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchong-Zhi Road, Shanghai 201203 (P. R. China)
    • Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchong-Zhi Road, Shanghai 201203 (P. R. China)
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Abstract

This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.

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