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Full Paper
Sniffing the Unique “Odor Print” of Non-Small-Cell Lung Cancer with Gold Nanoparticles
Article first published online: 24 AUG 2009
DOI: 10.1002/smll.200900937
Copyright © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Barash, O., Peled, N., Hirsch, F. R. and Haick, H. (2009), Sniffing the Unique “Odor Print” of Non-Small-Cell Lung Cancer with Gold Nanoparticles. Small, 5: 2618–2624. doi: 10.1002/smll.200900937
Publication History
- Issue published online: 11 NOV 2009
- Article first published online: 24 AUG 2009
- Manuscript Received: 2 JUN 2009
Funded by
- European Commission's FP6 program
- Alfred Mann Institute
- Technion's Russell Berrie Nanotechnology Institute
- SPORE
- IASLC
- Abstract
- Article
- References
- Cited By
Keywords:
- breath analysis;
- lung cancer;
- nanoparticles;
- sensors;
- volatile organic compounds
Abstract
A highly sensitive and fast-response array of sensors based on gold nanoparticles, in combination with pattern recognition methods, can distinguish between the odor prints of non-small-cell lung cancer and negative controls with 100% accuracy, with no need for preconcentration techniques. Additionally, preliminary results indicate that the same array of sensors might serve as a better tool for understanding the biochemical source of volatile organic compounds that might occur in cancer cells and appear in the exhaled breath, as compared to traditional spectrometry techniques. The reported results provide a launching pad to initiate a bedside tool that might be able to screen for early stages of lung cancer and allow higher cure rates. In addition, such a tool might be used for the immediate diagnosis of fresh (frozen) tissues of lung cancer in operating rooms, where a dichotomic diagnosis is crucial to guide surgeons.