Communication

Intracellular Silicon Chips in Living Cells†

  1. Rodrigo Gómez-Martínez1,‡,*,
  2. Patricia Vázquez2,‡,*,
  3. Marta Duch1,
  4. Alejandro Muriano3,
  5. Daniel Pinacho3,
  6. Nuria Sanvicens3,
  7. Francisco Sánchez-Baeza3,
  8. Patricia Boya2,
  9. Enrique J. de la Rosa2,
  10. Jaume Esteve1,
  11. Teresa Suárez2,§,*,
  12. José A. Plaza1,§,*

Article first published online: 21 DEC 2009

DOI: 10.1002/smll.200901041

Issue

Small

Small

Volume 6, Issue 4, pages 499–502, February 22, 2010

Additional Information

How to Cite

Gómez-Martínez, R., Vázquez, P., Duch, M., Muriano, A., Pinacho, D., Sanvicens, N., Sánchez-Baeza, F., Boya, P., de la Rosa, E. J., Esteve, J., Suárez, T. and Plaza, J. A. (2010), Intracellular Silicon Chips in Living Cells. Small, 6: 499–502. doi: 10.1002/smll.200901041

Author Information

  1. 1

    Instituto de Microelectrónica de Barcelona IMB-CNM (CSIC) Campus UAB s/n Cerdanyola, 08193 Barcelona (Spain)

  2. 2

    Centro de Investigaciones Biológicas, CIB (CSIC) C/Ramiro de Maeztu 9, 28040 Madrid (Spain)

  3. 3

    Instituto de Investigaciones Químicas y Ambientales de Barcelona IIQAB (CSIC) C/Jorge Girona, 18-26, 08034 Barcelona (Spain)

  1. ‡

    R.G.-M. and P.V. contributed equally to this work.

  2. §

    T.S. and J.A.P. are the project leaders.

*Instituto de Microelectrónica de Barcelona IMB-CNM (CSIC) Campus UAB s/n Cerdanyola, 08193 Barcelona (Spain).

  1. †

    This study was financed by the Spanish government through the MINAHE 2 project MEC-TEC2005-07996-CO2-01, MINAHE 3 project MEC-TEC2008-06883-CO3-01, the health research project SAF2007-66175 (to EJdlR), and the INTRACELL project CSIC-200550F0241 8 (to JE, EJdlR & FSB). We acknowledge support (PV) from the CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM). We want to thank Mayte Seisdedos, at the CIB, for her excellent assistance with confocal and time-lapse microscopy. We also thank the MEC-GICSERV program and the IMB-CNM clean-room staff.

  2. ‡

    R.G.-M. and P.V. contributed equally to this work.

  3. §

    T.S. and J.A.P. are the project leaders.

Publication History

  1. Issue published online: 22 FEB 2010
  2. Article first published online: 21 DEC 2009
  3. Manuscript Received: 16 JUN 2009

Funded by

  • Spanish government. Grant Numbers: MINAHE 2 project MEC-TEC2005-07996-CO2-01, MINAHE 3 project MEC-TEC2008-06883-CO3-01, SAF2007-66175, INTRACELL project CSIC-200550F0241 8

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Keywords:

  • biosensors;
  • cells;
  • microtechnology;
  • nanoparticles;
  • silicon chips
Thumbnail image of graphical abstract

Silicon-based chips offer high flexibility and versatility as they are based on semiconductor and MEMS technology. They can be top-down fabricated with well-controlled shape and size. Silicon microchips can be internalized into eukaryotic cells (see image) without interfering with cell viability. Engineered intracellular chips with different biomolecules attached to the surface can be used as intracellular sensors.

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