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Keywords:

  • assays;
  • dark-field microscopy;
  • DNA;
  • nanoparticles;
  • restriction enzymes
Thumbnail image of graphical abstract

A highly sensitive multiplexed DNA detection assay uses restriction-enzyme-encoded, DNA-modified magnetic microparticle and gold nanoparticle probes combined with dark-field nanoparticle imaging analysis (see picture). A sensitivity of 100 fM and high specificity of the detection targets are achieved.