Synthetic Viruslike Particles and Hybrid Constructs Based on Lipopeptide Self-Assembly


  • We thank EPSRC (Platform grant EP/C518748/1), the National Science Foundation (Agreement No. DMR-0454672) and the Science and Technology Facilities Council (STFC) for financial support, and the Institute Laue-Langevin (ILL) for providing beamtime and consumables.


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A method for fabricating hybrid monodisperse nanostructures comprising synthetic viruslike particles enclosed in an impermeable ultrathin amorphous calcium phosphate shell is described. The native and hybrid nanostructures are fully characterized at nanometer resolution and the permeability of the coronal layer is probed using fluorescence spectroscopy.