Communication

Nanopore Translocation and Force Spectroscopy Experiments in Microemulsion Droplets†

  1. Stephan Renner,
  2. Sandra Geltinger,
  3. Friedrich C. Simmel*

Article first published online: 4 DEC 2009

DOI: 10.1002/smll.200901435

Issue

Small

Small

Volume 6, Issue 2, pages 190–194, January 18, 2010

Additional Information

How to Cite

Renner, S., Geltinger, S. and Simmel, F. C. (2010), Nanopore Translocation and Force Spectroscopy Experiments in Microemulsion Droplets. Small, 6: 190–194. doi: 10.1002/smll.200901435

Author Information

  1. Lehrstuhl für Biolektronik, Physik Department TU München James-Franck-Straße, 85748 Garching (Germany)

*Lehrstuhl für Biolektronik, Physik Department TU München James-Franck-Straße, 85748 Garching (Germany).

  1. †

    Financial support from the Nanoinitiative Munich (NIM) is gratefully acknowledged. We thank Thomas Zeitzler for assistance with the electronic setup.

Publication History

  1. Issue published online: 14 JAN 2010
  2. Article first published online: 4 DEC 2009
  3. Manuscript Revised: 21 OCT 2009
  4. Manuscript Received: 4 AUG 2009

Funded by

  • Nanoinitiative Munich (NIM)

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Keywords:

  • aptamers;
  • DNA structures;
  • hemolysin;
  • microemulsions;
  • nanopores

Graphical Abstract

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Nanopore translocation experiments are performed using a novel setup based on microemulsion droplets. This scales down the required analyte volume to only a few picoliters and provides very stable membranes for single-molecule nanopore experiments. Using this setup, the stability of hairpin DNA and G-quadruplex DNA is studied by nanopore force spectroscopy.

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