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Full Paper
Near-Infrared-Resonant Gold/Gold Sulfide Nanoparticles as a Photothermal Cancer Therapeutic Agent
Article first published online: 22 FEB 2010
DOI: 10.1002/smll.200901557
Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Gobin, A. M., Watkins, E. M., Quevedo, E., Colvin, V. L. and West, J. L. (2010), Near-Infrared-Resonant Gold/Gold Sulfide Nanoparticles as a Photothermal Cancer Therapeutic Agent. Small, 6: 745–752. doi: 10.1002/smll.200901557
Publication History
- Issue published online: 23 MAR 2010
- Article first published online: 22 FEB 2010
- Manuscript Revised: 5 JAN 2010
- Manuscript Received: 20 AUG 2009
Funded by
- DOD CDMRP in Breast Cancer. Grant Number: DMI-0319965
- NSF NSEC Center for Biological and Environmental Nanotechnology (CBEN). Grant Numbers: EEC-0647452, NIH 5R01CA109385
- Abstract
- Article
- References
- Cited By
Keywords:
- cancer therapy;
- core/shell materials;
- gold sulfide;
- nanoparticles
Abstract
The development and optimization of near-infrared (NIR)-absorbing nanoparticles for use as photothermal cancer therapeutic agents has been ongoing. This work exploits the properties of gold/gold sulfide NIR-absorbing nanoparticles (≈35–55 nm) that provide higher absorption (98% absorption and 2% scattering for gold/gold sulfide versus 70% absorption and 30% scattering for gold/silica nanoshells) as well as potentially better tumor penetration. The ability to ablate tumor cells in vitro and efficacy for photothermal cancer therapy is demonstrated, and an in vivo model shows significantly increased long-term, tumor-free survival. Furthermore, enhanced circulation and biodistribution is observed in vivo. This class of NIR-absorbing nanoparticles has the potential to improve upon photothermal tumor ablation for cancer therapy.