Communication

Bioinspired Nanocorals with Decoupled Cellular Targeting and Sensing Functionality†

  1. Liz Y. Wu,
  2. Benjamin M. Ross,
  3. SoonGweon Hong,
  4. Luke P. Lee*

Article first published online: 27 JAN 2010

DOI: 10.1002/smll.200901604

Issue

Small

Small

Volume 6, Issue 4, pages 503–507, February 22, 2010

Additional Information

How to Cite

Wu, L. Y., Ross, B. M., Hong, S. and Lee, L. P. (2010), Bioinspired Nanocorals with Decoupled Cellular Targeting and Sensing Functionality. Small, 6: 503–507. doi: 10.1002/smll.200901604

Author Information

  1. Biomolecular Nanotechnology Center, Berkeley Sensor & Actuator Center, and Department of Bioengineering University of California-Berkeley 442 Stanley Hall, Berkeley, CA 94720 (USA)

*Biomolecular Nanotechnology Center, Berkeley Sensor & Actuator Center, and Department of Bioengineering University of California-Berkeley 442 Stanley Hall, Berkeley, CA 94720 (USA).

  1. †

    LYW and BMR contributed equally to this work. This work was funded by the National Institutes of Health Nanomedicine Development Center for the Optical Control of Biological Function (PN2 EY018241) and DARPA SERS S&T Fundamental Program under LLNL Subcontract #B573237. LYW acknowledges support from a Taiwan Merit Scholarship. The authors acknowledge Somin Eunice Lee for technical insight on specific recognition of breast carcinoma cells by anti-HER-2 labeled probes and David Y. Liang for his assistance in SERS data analysis.

Publication History

  1. Issue published online: 22 FEB 2010
  2. Article first published online: 27 JAN 2010
  3. Manuscript Revised: 19 NOV 2009
  4. Manuscript Received: 26 AUG 2009

Funded by

  • National Institutes of Health Nanomedicine Development Center for the Optical Control of Biological Function. Grant Number: PN2 EY018241
  • DARPA SERS S&T Fundamental Program. Grant Number: #B573237

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Keywords:

  • cellular sensing;
  • molecular recognition;
  • nanoplasmonic probes;
  • optical antennas;
  • surface-enhanced Raman spectroscopy (SERS)
Thumbnail image of graphical abstract

Nanocorals demonstrate independent cell-targeting and label-free biomolecular sensing capabilities. The highly roughened gold region of the nanocoral increases the adsorption capacity and causes a strong surface-enhanced Raman spectroscopy (SERS) signal. The polystyrene region can adsorb antibodies, allowing the nanocoral to specifically bind to receptors on the cancer cell membrane making nanocorals multifunctional nanosensors for cellular diagnostics and treatment evaluation.

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