Bioinspired Nanocorals with Decoupled Cellular Targeting and Sensing Functionality

Authors

  • Liz Y. Wu,

    1. Biomolecular Nanotechnology Center, Berkeley Sensor & Actuator Center, and Department of Bioengineering University of California-Berkeley 442 Stanley Hall, Berkeley, CA 94720 (USA)
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  • Benjamin M. Ross,

    1. Biomolecular Nanotechnology Center, Berkeley Sensor & Actuator Center, and Department of Bioengineering University of California-Berkeley 442 Stanley Hall, Berkeley, CA 94720 (USA)
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  • SoonGweon Hong,

    1. Biomolecular Nanotechnology Center, Berkeley Sensor & Actuator Center, and Department of Bioengineering University of California-Berkeley 442 Stanley Hall, Berkeley, CA 94720 (USA)
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  • Luke P. Lee

    Corresponding author
    1. Biomolecular Nanotechnology Center, Berkeley Sensor & Actuator Center, and Department of Bioengineering University of California-Berkeley 442 Stanley Hall, Berkeley, CA 94720 (USA)
    • Biomolecular Nanotechnology Center, Berkeley Sensor & Actuator Center, and Department of Bioengineering University of California-Berkeley 442 Stanley Hall, Berkeley, CA 94720 (USA).
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  • LYW and BMR contributed equally to this work. This work was funded by the National Institutes of Health Nanomedicine Development Center for the Optical Control of Biological Function (PN2 EY018241) and DARPA SERS S&T Fundamental Program under LLNL Subcontract #B573237. LYW acknowledges support from a Taiwan Merit Scholarship. The authors acknowledge Somin Eunice Lee for technical insight on specific recognition of breast carcinoma cells by anti-HER-2 labeled probes and David Y. Liang for his assistance in SERS data analysis.

Abstract

original image

Nanocorals demonstrate independent cell-targeting and label-free biomolecular sensing capabilities. The highly roughened gold region of the nanocoral increases the adsorption capacity and causes a strong surface-enhanced Raman spectroscopy (SERS) signal. The polystyrene region can adsorb antibodies, allowing the nanocoral to specifically bind to receptors on the cancer cell membrane making nanocorals multifunctional nanosensors for cellular diagnostics and treatment evaluation.

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