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Mesoporous Silica Nanoparticles Facilitate Delivery of siRNA to Shutdown Signaling Pathways in Mammalian Cells

Authors

  • Christopher Hom,

    Corresponding author
    1. Department of Microbiology, Immunology, and Molecular Genetics California NanoSystems Institute, JCCC University of California, Los Angeles 609 Charles E. Young Drive East, Los Angeles, CA 90095 (USA)
    • Department of Microbiology, Immunology, and Molecular Genetics California NanoSystems Institute, JCCC University of California, Los Angeles 609 Charles E. Young Drive East, Los Angeles, CA 90095 (USA).
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  • Jie Lu,

    1. Department of Microbiology, Immunology, and Molecular Genetics California NanoSystems Institute, JCCC University of California, Los Angeles 609 Charles E. Young Drive East, Los Angeles, CA 90095 (USA)
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  • Monty Liong,

    1. Department of Chemistry and Biochemistry California NanoSystems Institute University of California, Los Angeles 605 Charles E. Young Drive East, Los Angeles, CA 90095 (USA)
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  • Hanzhi Luo,

    1. School of Basic Medical Sciences Health Science Center, Peking University 38 Xueyuan Road, Haidian District, Beijing 100191 (P.R. China)
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  • Zongxi Li,

    1. Department of Chemistry and Biochemistry California NanoSystems Institute University of California, Los Angeles 605 Charles E. Young Drive East, Los Angeles, CA 90095 (USA)
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  • Jeffrey I. Zink,

    Corresponding author
    1. Department of Chemistry and Biochemistry California NanoSystems Institute University of California, Los Angeles 605 Charles E. Young Drive East, Los Angeles, CA 90095 (USA)
    • Department of Chemistry and Biochemistry California NanoSystems Institute University of California, Los Angeles 605 Charles E. Young Drive East, Los Angeles, CA 90095 (USA).
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  • Fuyuhiko Tamanoi

    Corresponding author
    1. Department of Microbiology, Immunology, and Molecular Genetics California NanoSystems Institute, JCCC University of California, Los Angeles 609 Charles E. Young Drive East, Los Angeles, CA 90095 (USA)
    • Department of Microbiology, Immunology, and Molecular Genetics California NanoSystems Institute, JCCC University of California, Los Angeles 609 Charles E. Young Drive East, Los Angeles, CA 90095 (USA).
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  • C.H. and J.L. contributed equally to this work. This work was supported by US NIH grant CA41996 and CA 133697, NSF grant DMR 0346601, and the UC Lead Campus for Nanotoxicology Training and Research, funded by UC TSR&TP and a gift from Nanopacific Holding Inc.

Abstract

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A nanocomplex assembly of polyethylenimine and mesoporous silica nanoparticles are used to successfully protect and deliver siRNA into human cells, effectively shutting down both exogenous and endogenous gene signal.

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