Cowpea Mosaic Virus Unmodified Empty Viruslike Particles Loaded with Metal and Metal Oxide


  • This work was supported by the Biotechnology and Biological Sciences Research Council, UK (Core Strategic Grant to the John Innes Centre, G.P.L. and D.J.E. and JIC DTG, A. A. A. A.) and the Trustees of the John Innes Foundation (F.S.). J. Elaine Barclay, Keith Saunders, Pooja Saxena, Abdul Rasheed (JIC), Mike Ridout (Institute of Food Research, Norwich) and Bertrand Leze (Environmental Sciences, University of East Anglia) are acknowledged for technical assistance.


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Empty (devoid of RNA) viruslike particles (eVLPs) of Cowpea mosaic virus can now be obtained readily. CPMV can encapsulate, within the protein capsid, cobalt or iron oxide by environmentally benign processes. The external surface also remains amenable to chemical modification. The development of eVLPs for targeted delivery of therapeutic agents is now a reality.