This work was supported by the Biotechnology and Biological Sciences Research Council, UK (Core Strategic Grant to the John Innes Centre, G.P.L. and D.J.E. and JIC DTG, A. A. A. A.) and the Trustees of the John Innes Foundation (F.S.). J. Elaine Barclay, Keith Saunders, Pooja Saxena, Abdul Rasheed (JIC), Mike Ridout (Institute of Food Research, Norwich) and Bertrand Leze (Environmental Sciences, University of East Anglia) are acknowledged for technical assistance.
Cowpea Mosaic Virus Unmodified Empty Viruslike Particles Loaded with Metal and Metal Oxide†
Article first published online: 8 MAR 2010
Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 6, Issue 7, pages 818–821, April 9, 2010
How to Cite
Aljabali, A. A. A., Sainsbury, F., Lomonossoff, G. P. and Evans, D. J. (2010), Cowpea Mosaic Virus Unmodified Empty Viruslike Particles Loaded with Metal and Metal Oxide. Small, 6: 818–821. doi: 10.1002/smll.200902135
- Issue published online: 26 MAR 2010
- Article first published online: 8 MAR 2010
- Manuscript Revised: 19 JAN 2010
- Manuscript Received: 12 NOV 2009
Empty (devoid of RNA) viruslike particles (eVLPs) of Cowpea mosaic virus can now be obtained readily. CPMV can encapsulate, within the protein capsid, cobalt or iron oxide by environmentally benign processes. The external surface also remains amenable to chemical modification. The development of eVLPs for targeted delivery of therapeutic agents is now a reality.