Radiation-Luminescence-Excited Quantum Dots for in vivo Multiplexed Optical Imaging

Authors

  • Hongguang Liu,

    1. Molecular Imaging Program at Stanford (MIPS)Department of Radiology Stanford University Medical Center California, LA 94305 (USA)
    2. Institute of Radiation Medicine Chinese Academy of Medical Sciences Peking Union Medical College Tsinghua University, Tianjin, 300192 (P.R. China)
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  • Xiaofen Zhang,

    1. Molecular Imaging Program at Stanford (MIPS)Department of Radiology Stanford University Medical Center California, LA 94305 (USA)
    2. Institute of Radiation Medicine Chinese Academy of Medical Sciences Peking Union Medical College Tsinghua University, Tianjin, 300192 (P.R. China)
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  • Bengang Xing,

    1. Division of Chemistry and Biological chemistry School of Physical & Mathematical Sciences Nanyang Technological University Singapore 637371 (Singapore)
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  • Peizhen Han,

    1. Institute of Radiation Medicine Chinese Academy of Medical Sciences Peking Union Medical College Tsinghua University, Tianjin, 300192 (P.R. China)
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  • Sanjiv Sam Gambhir,

    1. Molecular Imaging Program at Stanford (MIPS)Department of Radiology Stanford University Medical Center California, LA 94305 (USA)
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  • Zhen Cheng

    Corresponding author
    1. Molecular Imaging Program at Stanford (MIPS)Department of Radiology Stanford University Medical Center California, LA 94305 (USA)
    • Molecular Imaging Program at Stanford (MIPS)Department of Radiology Stanford University Medical Center California, LA 94305 (USA).
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  • This work was funded in part by the National Cancer Institute (NCI) R21 CA121842 (to Z.C.), NCI Center of Cancer Nanotechnology Excellence Grant U54 CA119367 (to S.S.G.), an A*Star BMRC (07/1/22/19/534) grant from Singapore (to B.X.), and the China Scholarship Council fellowship (to H.L.).

Abstract

original image

A new method to illuminate quantum dots (QDs) by radiation luminescence as an internal light source is reported. The excited QDs can produce fluorescence for both in vitro and in vivo imaging. This study provides an alternate strategy for the design of self-illuminated optical imaging agents. Radiation-luminescence-excited QDs can also be readily adapted for dual-modality imaging.

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