This work was supported by the National Science Foundation (sensor fabrication, biological materials) under Award No. ECCS-082390 and by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering (AC impedance analysis) under Award No. DE-FG-02-01ER45935. Hunter College infrastructure is supported by the National Institutes of Health, the RCMI program (G12-RR003037-245476). R.R. acknowledges a postdoctoral fellowship from the Spanish Ministerio de Ciencia e Innovación and Fundación Española para la Ciencia y la Tecnología.
Peptide-Nanotube Biochips for Label-Free Detection of Multiple Pathogens†
Article first published online: 3 MAY 2010
Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 6, Issue 10, pages 1092–1095, May 21 2010
How to Cite
de la Rica, R., Pejoux, C., Fernandez-Sanchez, C., Baldi, A. and Matsui, H. (2010), Peptide-Nanotube Biochips for Label-Free Detection of Multiple Pathogens. Small, 6: 1092–1095. doi: 10.1002/smll.201000151
- Issue published online: 19 MAY 2010
- Article first published online: 3 MAY 2010
- Manuscript Received: 31 JAN 2010
Peptide nanotubes are integrated with microfabricated transducer arrays for bacterial detection. On each microelectrode of the array, circulating antibody-modified peptide nanotubes agglutinate bacteria as pathogen catchers and generate an impedance signal on the transducer. The pathogen microarray can detect as few as 102 cells of E. coli or S. typhi within one hour and the sensor chip can be easily reused for multiple measurements.