Communication

Blood Purification Using Functionalized Core/Shell Nanomagnets†

  1. Inge K. Herrmann1,‡,
  2. Martin Urner2,3,‡,
  3. Fabian M. Koehler1,
  4. Melanie Hasler2,3,
  5. Birgit Roth-Z'Graggen2,3,
  6. Robert N. Grass1,
  7. Urs Ziegler4,
  8. Beatrice Beck-Schimmer2,3,§,
  9. Wendelin J. Stark1,§,*

Article first published online: 17 JUN 2010

DOI: 10.1002/smll.201000438

Issue

Small

Small

Volume 6, Issue 13, pages 1388–1392, July 5, 2010

Additional Information

How to Cite

Herrmann, I. K., Urner, M., Koehler, F. M., Hasler, M., Roth-Z'Graggen, B., Grass, R. N., Ziegler, U., Beck-Schimmer, B. and Stark, W. J. (2010), Blood Purification Using Functionalized Core/Shell Nanomagnets. Small, 6: 1388–1392. doi: 10.1002/smll.201000438

Author Information

  1. 1

    Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland)

  2. 2

    Institute of Anesthesiology University Hospital Zurich, Zurich (Switzerland)

  3. 3

    Institute of Physiology, Zurich Center for Integrative Human Physiology University of Zurich, Zurich (Switzerland)

  4. 4

    Center for Microscopy and Image Analysis University of Zurich, Zurich (Switzerland)

  1. ‡

    These authors contributed equally to this work.

  2. §

    These authors contributed equally to this work as senior authors.

*Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Wolfgang-Pauli-Strasse 10, 8093 Zurich (Switzerland).

  1. †

    We thank S. Jermann and M. Rossier for helpful discussions. C. Booy, L. Reyes, and G. Barmettler (electron microscopy) are kindly acknowledged for excellent technical support.

  2. ‡

    These authors contributed equally to this work.

  3. §

    These authors contributed equally to this work as senior authors.

Publication History

  1. Issue published online: 29 JUN 2010
  2. Article first published online: 17 JUN 2010
  3. Manuscript Revised: 20 APR 2010
  4. Manuscript Received: 16 MAR 2010

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Keywords:

  • in vivo extraction;
  • magnetochemistry;
  • nanomedicine;
  • nanoparticles;
  • therapy
Thumbnail image of graphical abstract

Injection of functional nanomagnets in human blood enables selective removal of disease-causing metals, overdosed drugs, and proteins at the (sub-)nanomolar level. This direct in vivo extraction provides a powerful alternative to classical pharmaceutical treatments as disease-causing agents are removed from the organism rather than treating symptoms from exposure. A number of clinically relevant assays demonstrate blood compatibility of the functional nanomagnets.

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