The Role of Surface Functionality on Acute Cytotoxicity, ROS Generation and DNA Damage by Cationic Gold Nanoparticles

Authors

  • Apiwat Chompoosor,

    1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-2058, USA
    Search for more papers by this author
  • Krishnendu Saha,

    1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-2058, USA
    Search for more papers by this author
  • Partha S. Ghosh,

    1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-2058, USA
    Search for more papers by this author
  • Dylan J. Macarthy,

    1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-2058, USA
    Search for more papers by this author
  • Oscar R. Miranda,

    1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-2058, USA
    Search for more papers by this author
  • Zheng-Jiang Zhu,

    1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-2058, USA
    Search for more papers by this author
  • Kathleen F. Arcaro,

    1. Department of Veterinary & Animal Sciences, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-4860, USA
    Search for more papers by this author
  • Vincent M. Rotello

    Corresponding author
    1. Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-2058, USA
    • Department of Veterinary & Animal Sciences University of Massachusetts Amherst 710 North Pleasant Street, Amherst, MA 01003, USA Fax: (+1) 413-545-4860, USA.
    Search for more papers by this author

Abstract

original image

A poisoned chalice? Surface functionalization of 2 nm gold nanoparticles is an important determinant of their acute toxicity and genotoxicity. These attributes need to be considered for their use as carriers, and provide new direction for the design of therapeutics.

Ancillary