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Keywords:

  • reactive oxygen species;
  • gold nanoparticles;
  • cytotoxicity;
  • DNA damage;
  • comet assay
Thumbnail image of graphical abstract

A poisoned chalice? Surface functionalization of 2 nm gold nanoparticles is an important determinant of their acute toxicity and genotoxicity. These attributes need to be considered for their use as carriers, and provide new direction for the design of therapeutics.