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Keywords:

  • DNA nanostructures;
  • nanotechnology;
  • multidrug delivery;
  • self-assembly;
  • siRNA
Thumbnail image of graphical abstract

Multifunctional DNAsomes: DNA–lipid amphiphiles self-assemble into novel “DNAsomes”—liposome-like core–shell structures with subunits composed of branched DNA–lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA–RNA base-pairing, enabling efficient co-delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.