Communication

DNAsomes: Multifunctional DNA-Based Nanocarriers

  1. Young Hoon Roh1,
  2. Jong Bum Lee1,
  3. Pichamon Kiatwuthinon1,
  4. Mark R. Hartman1,
  5. Judy J. Cha2,
  6. Soong Ho Um3,
  7. David A. Muller4,
  8. Dan Luo1,*

Article first published online: 25 NOV 2010

DOI: 10.1002/smll.201000752

Issue

Small

Small

Volume 7, Issue 1, pages 74–78, January 3, 2011

Additional Information

How to Cite

Roh, Y. H., Lee, J. B., Kiatwuthinon, P., Hartman, M. R., Cha, J. J., Um, S. H., Muller, D. A. and Luo, D. (2011), DNAsomes: Multifunctional DNA-Based Nanocarriers. Small, 7: 74–78. doi: 10.1002/smll.201000752

Author Information

  1. 1

    Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, 14853, USA

  2. 2

    Department of Materials Science and Engineering, Stanford University, Stanford, California, 94305, USA

  3. 3

    Department of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 500–712, Korea

  4. 4

    Department of Applied and Engineering, PhysicsCornell University, Ithaca, New York, 14853, USA

*Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, 14853, USA.

Publication History

  1. Issue published online: 27 DEC 2010
  2. Article first published online: 25 NOV 2010
  3. Manuscript Revised: 6 JUL 2010
  4. Manuscript Received: 2 MAY 2010

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Keywords:

  • DNA nanostructures;
  • nanotechnology;
  • multidrug delivery;
  • self-assembly;
  • siRNA
Thumbnail image of graphical abstract

Multifunctional DNAsomes: DNA–lipid amphiphiles self-assemble into novel “DNAsomes”—liposome-like core–shell structures with subunits composed of branched DNA–lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA–RNA base-pairing, enabling efficient co-delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.

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