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Poly(Methacrylic Acid) Polymer Hydrogel Capsules: Drug Carriers, Sub-compartmentalized Microreactors, Artificial Organelles

Authors

  • Alexander N. Zelikin,

    Corresponding author
    1. Interdisciplinary Nanoscience Centre (iNano), Aarhus University, Aarhus C 8000, Denmark
    2. Department of Chemistry, Aarhus University, Aarhus C 8000, Denmark
    Current affiliation:
    1. Former address: Department of Chemical Engineering, The University of Melbourne, Parkville 3010, Australia
    • Interdisciplinary Nanoscience Centre (iNano), Aarhus University, Aarhus C 8000, Denmark.
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  • Andrew D. Price,

    1. Department of CINT S cience, Sandia National Laboratories, Albuquerque, NM 87185, USA
    Current affiliation:
    1. Former address: Department of Chemical Engineering, The University of Melbourne, Parkville 3010, Australia
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  • Brigitte Städler

    Corresponding author
    1. Interdisciplinary Nanoscience Centre (iNano), Aarhus University, Aarhus C 8000, Denmark
    Current affiliation:
    1. Former address: Department of Chemical Engineering, The University of Melbourne, Parkville 3010, Australia
    • Interdisciplinary Nanoscience Centre (iNano), Aarhus University, Aarhus C 8000, Denmark.
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Abstract

Multilayered polymer capsules attract significant research attention and are proposed as candidate materials for diverse biomedical applications, from targeted drug delivery to microencapsulated catalysis and sensors. Despite tremendous efforts, the studies which extend beyond proof of concept and report on the use of polymer capsules in drug delivery are few, as are the developments in encapsulated catalysis with the use of these carriers. In this Concept article, the recent successes of poly(methacrylic acid) hydrogel capsules as carrier vessels for delivery of therapeutic cargo, creation of microreactors, and assembly of sub-compartmentalized cell mimics are discussed. The developed technologies are outlined, successful applications of these capsules are highlighted, capsules properties which contribute to their performance in diverse applications are discussed, and further directions and plausible developments in the field are suggested.

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