Polyhydroxy Fullerenes for Non-Invasive Cancer Imaging and Therapy

Authors

  • Vijay Krishna,

    Corresponding author
    1. Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, Florida 32611, Phone: 352-846-1194, Fax: 352-846-1196
    • Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, Florida 32611, Phone: 352-846-1194, Fax: 352-846-1196
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  • Amit Singh,

    1. Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, Florida 32611, Phone: 352-846-1194, Fax: 352-846-1196
    2. Materials Science and Engineering, University of Florida
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  • Parvesh Sharma,

    1. Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, Florida 32611, Phone: 352-846-1194, Fax: 352-846-1196
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  • Nobutaka Iwakuma,

    1. Division of Surgical Oncology, Department of Surgery, University of Florida
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  • Qiang Wang,

    1. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
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  • Qizhi Zhang,

    1. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
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  • Jacquelyn Knapik,

    1. Department of Pathology, Immunology and Laboratory Medicine, University of Florida
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  • Huabei Jiang,

    1. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
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  • Stephen R. Grobmyer,

    1. Division of Surgical Oncology, Department of Surgery, University of Florida
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  • Ben Koopman,

    1. Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, Florida 32611, Phone: 352-846-1194, Fax: 352-846-1196
    2. Department of Environmental Engineering Sciences, University of Florida
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  • Brij Moudgil

    1. Particle Engineering Research Center, 205 Particle Science and Technology Building, PO Box 116135, University of Florida, Gainesville, Florida 32611, Phone: 352-846-1194, Fax: 352-846-1196
    2. Materials Science and Engineering, University of Florida
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Abstract

original image

The novel optical properties of polyhydroxy fullerenes (PHF)—which are water-soluble, biodegradable and antioxidant—are applied for imaging and therapy of cancer. Tumors injected with PHF are imaged with photoacoustic tomography (PAT) and photothermally treated with near-infrared (NIR) laser. Tumor size decreases up to 72% within two hours of treatment, with only a blister visible after 20 hours.

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