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Self-Assembled Hybrid Structures of DNA Block-Copolymers and Nanoparticles with Enhanced DNA Binding Properties

Authors

  • Xi-Jun Chen,

    1. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, PA, 19104, USA, Fax: (215) 573–6743
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  • Brenda L. Sanchez-Gaytan,

    1. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, PA, 19104, USA, Fax: (215) 573–6743
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  • Sara E. N. Hayik,

    1. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, PA, 19104, USA, Fax: (215) 573–6743
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  • Michael Fryd,

    1. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, PA, 19104, USA, Fax: (215) 573–6743
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  • Bradford B. Wayland,

    1. Department of Chemistry, Temple University, Beury Hall 130, 1901 N. 13th Street, Philadelphia, PA 19122, USA
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  • So-Jung Park

    Corresponding author
    1. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, PA, 19104, USA, Fax: (215) 573–6743
    • Department of Chemistry University of Pennsylvania 231 S. 34th Street Philadelphia, PA, 19104, USA Fax: (215) 573–6743.
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Abstract

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The self-assembly of DNA block-copolymers and nanoparticles yields hybrid nanostructures with useful properties of incorporated nanoparticles and a high density DNA layer on the exterior. Remarkably, they exhibit drastically enhanced binding capability to complementary DNA even at very low salt concentrations where isolated DNA strands do not form duplex structure. This extraordinary binding capability along with the high selectivity allows for efficient duplex DNA detection.

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