pH-Sensitive Nanoflash for Tumoral Acidic pH Imaging in Live Animals

Authors

  • Jin Young Ko,

    1. Biomedical Research Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seould 136 791, Republic of Korea
    Search for more papers by this author
  • Sangjin Park,

    1. Biomedical Research Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seould 136 791, Republic of Korea
    Search for more papers by this author
  • Hyejung Lee,

    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130–701, Republic of Korea
    Search for more papers by this author
  • Heebeom Koo,

    1. Biomedical Research Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seould 136 791, Republic of Korea
    Search for more papers by this author
  • Min Sang Kim,

    1. Theranostic Macromolecules Research Center, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440–746, Republic of Korea
    Search for more papers by this author
  • Kuiwon Choi,

    1. Biomedical Research Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seould 136 791, Republic of Korea
    Search for more papers by this author
  • Ick Chan Kwon,

    1. Biomedical Research Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seould 136 791, Republic of Korea
    Search for more papers by this author
  • Seo Young Jeong,

    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130–701, Republic of Korea
    Search for more papers by this author
  • Kwangmeyung Kim,

    Corresponding author
    1. Biomedical Research Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seould 136 791, Republic of Korea
    • Biomedical Research Center, Korea Institute of Science and Technology, 39–1 Hawolgok-dong, Seongbuk-gu, Seould 136 791, Republic of Korea
    Search for more papers by this author
  • Doo Sung Lee

    Corresponding author
    1. Theranostic Macromolecules Research Center, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440–746, Republic of Korea
    • Theranostic Macromolecules Research Center, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440–746, Republic of Korea.
    Search for more papers by this author

Abstract

original image

Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

Ancillary