Get access

Cell Response to Carbon Nanotubes: Size-Dependent Intracellular Uptake Mechanism and Subcellular Fate

Authors

  • Bin Kang,

    1. College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
    2. School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Search for more papers by this author
  • Shuquan Chang,

    1. College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
    Search for more papers by this author
  • Yaodong Dai,

    Corresponding author
    1. College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
    • College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
    Search for more papers by this author
  • Decai Yu,

    1. Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China
    Search for more papers by this author
  • Da Chen

    1. College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
    Search for more papers by this author

Abstract

original image

The intracellular uptake and subcellular localization of carbon nanotubes strongly depend on the physical size of the materials. Multiwalled carbon nanotubes (MWNTs; 0.5–2 μm in length, 10–30 nm in diameter) are excluded from the interior of the cell; long single-walled carbon nanotubes (L-SWNTs) of length 100–200 nm (1–3 nm in diameter) are only internalized into cytoplasm, whereas short ones (S-SWNTs) of length 50–100 nm partly reside in the cell nucleus.

Get access to the full text of this article

Ancillary