Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI-Grafted Graphene Oxide



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Loading and delivery of Bcl-2-targeted short interfering RNA (siRNA) and anticancer drug doxorubicin (DOX) by polyethylenimine (PEI)-conjugated graphene oxide (PEI-GO) is studied. A higher knockdown efficiency of siRNA delivered by PEI-GO than by PEI is achieved. Sequential delivery of siRNA and DOX by the PEI-GO nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy.