Quantum dots: Dynamic Visualization of RGD-Quantum Dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models Using Intravital Microscopy (Small 20/2010)

Authors

  • Bryan Ronain Smith,

    1. The Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Department of Bioengineering, Stanford University School of Medicine, The James H. Clark Center, 318 Campus Drive, E-150, East Wing, 1st Floor, Stanford, CA 94305–5427, USA
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  • Zhen Cheng,

    1. The Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Department of Bioengineering, Stanford University School of Medicine, The James H. Clark Center, 318 Campus Drive, E-150, East Wing, 1st Floor, Stanford, CA 94305–5427, USA
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  • Abhijit De,

    1. The Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Department of Bioengineering, Stanford University School of Medicine, The James H. Clark Center, 318 Campus Drive, E-150, East Wing, 1st Floor, Stanford, CA 94305–5427, USA
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  • Jarrett Rosenberg,

    1. The Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Department of Bioengineering, Stanford University School of Medicine, The James H. Clark Center, 318 Campus Drive, E-150, East Wing, 1st Floor, Stanford, CA 94305–5427, USA
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  • Sanjiv Sam Gambhir

    Corresponding author
    1. The Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Department of Bioengineering, Stanford University School of Medicine, The James H. Clark Center, 318 Campus Drive, E-150, East Wing, 1st Floor, Stanford, CA 94305–5427, USA
    • The Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program, and Department of Bioengineering, Stanford University School of Medicine, The James H. Clark Center, 318 Campus Drive, E-150, East Wing, 1st Floor, Stanford, CA 94305–5427, USA.
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Abstract

original image

The frontispiece image shows tumor (green) at the microscopic level in living mice. Within the tumor, blood vessels in red are easily visible. When targeted, nanoparticles (quantum dots, shown in white) bind as aggregates in a similar way to three different types of tumor (one example is shown at bottom left). However, when controls are used, very little binding takes place as shown in the other images. Data indicate that vascular targeting may be a robust and reliable method to promote nanoparticle accumulation in a tumor, as opposed to extravasation, which is shown to be highly heterogeneous. For more information, please read the Full Paper “Dynamic Visualization of RGD-Quantum Dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models Using Intravital Microscopy” by S. S. Gambhir and co-workers, beginning on page 2222.

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