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Keywords:

  • DNA structures;
  • nanostructures;
  • phosphorothioate;
  • proteins;
  • self-assembly
Thumbnail image of graphical abstract

Phosphorothioate-modified DNA and short bifunctional linkers are used to attach proteins to a DNA tetrahedron. Precise control of the position of and distance between protein modifications is achieved. This technique is simple, can be adapted to other DNA nanostructures, exhibits high yields, and the modification can be programmably placed within the structure.