Molecular Analysis of Blood with Micro-/Nanoscale Field-Effect-Transistor Biosensors

Authors

  • Matthew S. Makowski,

    1. Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA
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  • Albena Ivanisevic

    Corresponding author
    1. Department of Material Science and Engineering, North Carolina State University, Joint Department of Biomedical Engineering NCSU/UNC-CH, 911 Partner's Way Raleigh, NC 27695, USA
    • Department of Material Science and Engineering, North Carolina State University, Joint Department of Biomedical Engineering NCSU/UNC-CH, 911 Partner's Way Raleigh, NC 27695, USA.
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Abstract

Rapid and accurate molecular blood analysis is essential for disease diagnosis and management. Field-effect transistor (FET) biosensors are a type of device that promise to advance blood point-of-care testing by offering desirable characteristics such as portability, high sensitivity, brief detection time, low manufacturing cost, multiplexing, and label-free detection. By controlling device parameters, desired FET biosensor performance is obtained. This review focuses on the effects of sensing environment, micro-/nanoscale device structure, operation mode, and surface functionalization on device performance and long-term stability.

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