Using Charge to Control the Functional Properties of Self-Assembled Nanopores in Membranes

Authors

  • Michael X. Macrae,

    1. University of California – San Diego, Department of Chemistry and Biochemistry, La Jolla, CA 92093-0358, USA
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  • Diana Schlamadinger,

    1. University of California – San Diego, Department of Chemistry and Biochemistry, La Jolla, CA 92093-0358, USA
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  • Judy E. Kim,

    1. University of California – San Diego, Department of Chemistry and Biochemistry, La Jolla, CA 92093-0358, USA
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  • Michael Mayer,

    Corresponding author
    1. University of Michigan, Departments of Biomedical Engineering and Chemical Engineering, Ann Arbor, MI, 48109-2110, USA
    • University of Michigan, Departments of Biomedical Engineering and Chemical Engineering, Ann Arbor, MI, 48109-2110, USA
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  • Jerry Yang

    Corresponding author
    1. University of California – San Diego, Department of Chemistry and Biochemistry, La Jolla, CA 92093-0358, USA
    • University of California – San Diego, Department of Chemistry and Biochemistry, La Jolla, CA 92093-0358, USA.
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Abstract

original image

Light sensitive, semisynthetic ion channels allow for the modulation of multi­ple channel properties. Covalent attachment of a photoswitchable spiropyran group to the entrance of a gramicidin A ion channel enables reversible control of both conductance and channel lifetime, which show opposite trends in behavior at high and low salt concentrations.

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