Engineered Multifunctional Nanocarriers for Cancer Diagnosis and Therapeutics

Authors

  • Donglu Shi,

    1. The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, China
    2. Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati OH 45221, USA
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  • Nicholas M. Bedford,

    Corresponding author
    1. Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati OH 45221, USA
    • Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati OH 45221, USA.
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  • Hoon-Sung Cho

    1. Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
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Abstract

This article reviews advances in the design and development of multifunctional carbon-based and/or magnetic nanoparticle systems (or simply ‘nanocarriers’) for early cancer diagnosis and spatially and temporally controlled therapy. The critical issues in cancer diagnosis and treatment are addressed based on novel nanotechnologies such as real-time in-vivo imaging, drug storage and release, and specific cancer-cell targeting. The implementation of nanocarriers into animal models and the subsequent effectiveness in treating tumors is also reviewed. Recommendations for future research are given.

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