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More Effective Nanomedicines through Particle Design

Authors

  • Jin Wang,

    1. Department of Chemistry, Carolina Center of Cancer Nanotechnology Excellence, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599
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  • James D. Byrne,

    1. Department of Chemistry, Carolina Center of Cancer Nanotechnology Excellence, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599
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  • Mary E. Napier,

    1. Department of Chemistry, Carolina Center of Cancer Nanotechnology Excellence, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599
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  • Joseph M. DeSimone

    Corresponding author
    1. Department of Chemistry, Carolina Center of Cancer Nanotechnology Excellence, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599
    2. Department Pharmacology, Institute for Advanced Materials, Institute for Nanomedicine, University of North Carolina, Chapel Hill, NC 27599
    3. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695
    4. Sloan-Kettering Institute for Cancer Research, Memorial, Sloan-Kettering Cancer Center, New York, NY 10021
    • Department of Chemistry, Carolina Center of Cancer Nanotechnology Excellence, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.
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  • Dedicated to Dr. Mirkin

Abstract

Nanomedicine is an emerging field that applies concepts in nanotechnology to develop novel diagnostics and therapies. Physical and chemical properties of particles, including size, shape, modulus, surface charge and surface chemistry, play an important role in determining particle–cell interactions, cellular trafficking mechanisms, biodistribution, and pharmacokinetics. This discussion focuses on both nanoparticles and microparticles since microparticles can also provide many insights for the development of drug carriers and possess advantages over nanoparticles in certain applications. This review covers recent major advancement in the nanomedicine field and also highlights studies using the PRINT technology.

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