Acrylate-Facilitated Cellular Uptake of Gold Nanoparticles

Authors

  • Željka Krpetić,

    1. Centre for Nanoscale Science, Department of Chemistry, Crown Street,University of Liverpool, Liverpool, L69 7ZD, UK
    Current affiliation:
    1. Ž. K. and P. N. contributed equally to this work.
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  • Paola Nativo,

    1. Centre for Nanoscale Science, Department of Chemistry, Crown Street,University of Liverpool, Liverpool, L69 7ZD, UK
    Current affiliation:
    1. Ž. K. and P. N. contributed equally to this work.
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  • Ian A. Prior,

    1. Centre for Nanoscale Science, Department of Chemistry, Crown Street,University of Liverpool, Liverpool, L69 7ZD, UK
    2. Institute of Translational Research, University of Liverpool, Liverpool, L69 3BX, UK
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  • Mathias Brust

    Corresponding author
    1. Centre for Nanoscale Science, Department of Chemistry, Crown Street,University of Liverpool, Liverpool, L69 7ZD, UK
    • Centre for Nanoscale Science, Department of Chemistry, Crown Street,University of Liverpool, Liverpool, L69 7ZD, UK.
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Abstract

original image

Uptake of PEGylated gold nanoparticles by HeLa cells in the presence of acrylate is described. Nanoparticles that are usually not taken up readily cross the plasma membrane into the cytosol in the presence of acrylate. In addition, a method is described that allows the introduction of large amounts of pre-aggregated gold nanoparticles into the cells without compromising the cell viability.

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