Beauty is Skin Deep: A Surface Monolayer Perspective on Nanoparticle Interactions with Cells and Bio-macromolecules

Authors

  • Krishnendu Saha,

    1. Department of Chemistry, University of Massachusetts Amherst 710 North Pleasant Street, Amherst, MA 01003, USA, Tel: +1 413 545 2058, Fax: +1 413 545 4490
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  • Avinash Bajaj,

    1. Department of Chemistry, University of Massachusetts Amherst 710 North Pleasant Street, Amherst, MA 01003, USA, Tel: +1 413 545 2058, Fax: +1 413 545 4490
    2. Regional Centre for Biotechnology 180 Udyog Vihar Phase 1, Gurgaon-122016, Haryana, India
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  • Bradley Duncan,

    1. Department of Chemistry, University of Massachusetts Amherst 710 North Pleasant Street, Amherst, MA 01003, USA, Tel: +1 413 545 2058, Fax: +1 413 545 4490
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  • Vincent M. Rotello

    Corresponding author
    1. Department of Chemistry, University of Massachusetts Amherst 710 North Pleasant Street, Amherst, MA 01003, USA, Tel: +1 413 545 2058, Fax: +1 413 545 4490
    • Department of Chemistry, University of Massachusetts Amherst 710 North Pleasant Street, Amherst, MA 01003, USA, Tel: +1 413 545 2058, Fax: +1 413 545 4490.
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Abstract

Surface recognition of biosystems is a critical component in the development of novel biosensors and delivery vehicles, and for the therapeutic regulation of biological processes. Monolayer-protected nanoparticles present a highly versatile scaffold for selective interaction with bio-macromolecules and cells. Through the engineering of the monolayer surface, nanoparticles can be tailored for surface recognition of biomolecules and cells. This review highlights recent progress in nanoparticle–bio-macromolecule/cellular interactions, emphasizing the effect of the surface monolayer structure on the interactions with proteins, DNA, and cell surfaces. The extension of these tailored interactions to hybrid nanomaterials, biosensing platforms, and delivery vehicles is also discussed.

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