Glyco-DNA–Gold Nanoparticles: Lectin-Mediated Assembly and Dual-Stimuli Response

Authors

  • Katrin G. Witten,

    1. Institute of Inorganic Chemistry and JARA-FIT (Future Information, Technology), RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
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  • Claudia Rech,

    1. Laboratoy for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany
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  • Thomas Eckert,

    1. Institute of Physical Chemistry II, RWTH Aachen University, Landoltweg 2, 52074 Aachen, Germany
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  • Samir Charrak,

    1. Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
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  • Walter Richtering,

    1. Institute of Physical Chemistry II, RWTH Aachen University, Landoltweg 2, 52074 Aachen, Germany
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  • Lothar Elling,

    Corresponding author
    1. Laboratoy for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany
    • Laboratoy for Biomaterials, Institute of Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany.
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  • Ulrich Simon

    Corresponding author
    1. Institute of Inorganic Chemistry and JARA-FIT (Future Information, Technology), RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
    • Institute of Inorganic Chemistry and JARA-FIT (Future Information, Technology), RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
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Abstract

original image

The formation and properties of glyco-DNA–gold nanoparticles (NP) with a multivalent presentation of DNA-glyco ligands is presented. These particles are equipped with two reversible binding modes, which enable reversible dissociation by two independent external stimuli: temperature-induced DNA duplex melting and displacement of the DNA-glyco ligands from the carbohydrate recognition domains with free sugar.

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