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Influence of Nanostructure Morphology on Host Capacity and Kinetics of Guest Release

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Abstract

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Morphology-dependent drug loading capacities and release kinetics are observed from pH-responsive diblock copolymer-based nano-objects, derived from the same block copolymer precursor. Shell-crosslinked, rod-shaped nanostructures exhibit a higher doxorubicin-loading capacity and rate of release than do their spherical counterparts. The extent of crosslinking and the type of crosslinker is also demonstrated to affect the rate of release.

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