Optical Detection of Protein in Complex Media with Plasmonic Nanoparticle Dimers



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Actuatable gold nanoparticle dimers for protein sensing are presented. By monitoring the spectral blue shift in the hybridized bonding plasmon mode instead of the conventional refractive index changes on a single nanoparticle, dimers are shown to be able to detect target protein even in the presence of high levels of nonspecific binding in complex media such as serum.