Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

Authors

  • Yu Cheng,

    1. Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA, Fax: (+1) 216–368-3006
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  • Joseph D. Meyers,

    1. Center for Molecular Imaging, NFCR Center for Molecular Imaging at Case, Departments of Biomedical Engineering and Radiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
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  • Richard S. Agnes,

    1. Center for Molecular Imaging, NFCR Center for Molecular Imaging at Case, Departments of Biomedical Engineering and Radiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
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  • Tennyson L. Doane,

    1. Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA, Fax: (+1) 216–368-3006
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  • Malcolm E. Kenney,

    1. Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA, Fax: (+1) 216–368-3006
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  • Ann-Marie Broome,

    Corresponding author
    1. Center for Molecular Imaging, NFCR Center for Molecular Imaging at Case, Departments of Biomedical Engineering and Radiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    • Center for Molecular Imaging, NFCR Center for Molecular Imaging at Case, Departments of Biomedical Engineering and Radiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
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  • Clemens Burda,

    Corresponding author
    1. Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA, Fax: (+1) 216–368-3006
    • Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA, Fax: (+1) 216–368-3006
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  • James P. Basilion

    Corresponding author
    1. Center for Molecular Imaging, NFCR Center for Molecular Imaging at Case, Departments of Biomedical Engineering and Radiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    • Center for Molecular Imaging, NFCR Center for Molecular Imaging at Case, Departments of Biomedical Engineering and Radiology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
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Abstract

original image

EGF-modified Au NP–Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF–Au NP–Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers.

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