Mitochondria-Targeting Single-Walled Carbon Nanotubes for Cancer Photothermal Therapy

Authors

  • Feifan Zhou,

    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
    2. Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou 510631, China
    Current affiliation:
    1. These authors contributed equally to this work
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  • Shengnan Wu,

    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
    2. Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou 510631, China
    Current affiliation:
    1. These authors contributed equally to this work
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  • Baoyan Wu,

    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
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  • Wei R. Chen,

    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
    2. Biomedical Engineering Program, Department of Engineering and Physics, College of Mathematics and Science, University of Central Oklahoma, Edmond, OK 73034, USA
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  • Da Xing

    Corresponding author
    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
    2. Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou 510631, China
    • MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
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Abstract

Nanomaterials have recently attracted much attention as efficient transducers for cancer photothermal therapy, based on their intrinsic absorption properties in the near-infrared region. This study explores a novel therapy model with mitochondria-targeting single-walled carbon nanotubes (SWNTs), which act efficiently to convert 980-nm laser energy into heat and selectively destroy the target mitochondria, thereby inducing mitochondrial depolarization, cytochrome c release, and caspase 3 activation. The laser+SWNTs process affords remarkable efficacy in suppressing tumor growth in a breast cancer model, and results in complete tumor regression in some cases. Laser+SWNTs could prove to be a promising selective local treatment modality, while minimizing adverse side effects.

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